Qiupeng Lin

College of Agriculture, SCAU

 

Principal Investigator

 

Crop Genome Editing Lab   |   PI

 

Professor   |   Doctoral supervisor

| Introduction

Dr. Lin is a Professor in the College of Agriculture at South China Agricultural University. He received his B.S. degree in Life Science (Xiangqin Innovation Class) and M.S. degree in Botany from South China Normal University, supervised by Prof. Hongqing Li. In 2021, he obtained Ph.D. at Institute of Genetics and Developmental Biology,Chinese Academy of Sciences, supervised by Prof. Caixia Gao. In 2023, he completed postdoctoral research with Prof. Caixia Gao, and then started his lab in South China Agricultural University in the same year. Lin studies genome editing technology, especially in developing and optimizing precise CRISPR-based genome editing tools in plants, and applying in agricultural and therapeutic fields. He developed plant prime editors and increased their efficiency via multiple strategies. He also developed a serious of new genome editing technologies for biological research and crop breeding. He has published over 10 first author and co-first author papers in Cell, Nature Biotechnology, Nature Protocols, Molecular Cell, etc. and applied 4 PCT patents.


| Professional Career

  • 2023-Now Professor, College of Agriculture, South China Agricultural University
  • 2021-2023 Postdoctoral Fellow, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences

| Education history

  • 2017-2021 PhD in Genetics, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences
  • 2014-2017 M.Sc. in Botany, School of Life Science, South China Normal University
  • 2010-2014 B.Sc. in Life Science (Xiangqin Class), School of Life Science, South China Normal University

| Awards

  • 2023 Awarded Excellent Doctoral Dissertation of Chinese Academy of Sciences
  • 2021 Awarded Fellowship of China National Postdoctoral Program for Innovative Talents

| Publications

    (1 co-first author;* corresponding author)

  • 林秋鹏1*, 朱秀丽1, 马琳莎, 姚鹏程. (2023). 引导编辑系统研究进展. 华南农业大学学报 (Accepted).

  • Lin, Q.1, Zong, Y.1, Xue, C.1, Wang, S., Jin, S., Zhu, Z., Wang, Y., Anzalone, A.V., Raguram, A., Doman, J.L., Liu, D.R., and Gao, C.* (2020). Prime genome editing in rice and wheat. Nat. Biotechnol. 38, 582-585. (Trends in Plant Science亮点评述; F1000Prime推荐)

  • Lin, Q.1, Jin, S.1, Zong, Y.1, Yu, H.1, Zhu, Z., Liu, G., Kou, L., Wang, Y., Qiu, J.L., Li, J.*, and Gao, C.* (2021). High-efficiency prime editing with optimized, paired pegRNAs in plants. Nat. Biotechnol. 39, 923-927. (高被引论文; Nature Methods亮点评述)

  • Huang, J.1, Lin, Q.1, Fei, H.1, He, Z.1, Xu, H., Li, Y., Qu, K., Han, P., Gao, Q., Li, B., Liu, G., Zhang, L., Hu, J., Zhang, R., Zuo, E., Luo, Y., Ran, Y., Qiu, J.L., Zhao, K.T.*, and Gao, C.* (2023). Discovery of deaminase functions by structure-based protein clustering. Cell. 186, 3182-3195.e14. (Trends in Plant Science亮点评述; F1000Prime推荐)

  • Jin, S.1, Lin, Q.1, Luo, Y.1, Zhu, Z.1, Liu, G., Li, Y., Chen, K., Qiu, J.L., and Gao, C.* (2021). Genome-wide specificity of prime editors in plants. Nat. Biotechnol. 39, 1292-1299. (高被引论文; Nature Methods亮点评述)

  • Wang, S.1, Zong, Y.1, Lin, Q.1, Zhang, H.1, Chai, Z., Zhang, D., Chen, K., Qiu,J.L., and Gao, C.* (2020). Precise, predictable multi-nucleotide deletions in rice and wheat using APOBEC-Cas9. Nat. Biotechnol. 38, 1460-1465.

  • Lin, Q.1, Zhu, Z.1, Liu, G.1, Sun, C., Lin, D., Xue, C., Li, S., Zhang, D., Gao, C., Wang, Y.*, and Qiu, J.L.* (2021). Genome editing in plants with MAD7 nuclease. J. Genet. Genomics. 48, 444-451. (封面故事)

  • Xu, Y.1, Lin, Q.1, Li, X., Wang, F., Chen, Z., Wang, J., Li, W., Fan, F., Tao, Y., Jiang, Y., Wei, X., Zhang, R., Zhu, Q.H., Bu, Q.*, Yang, J.*, and Gao, C.* (2021). Fine-tuning the amylose content of rice by precise base editing of the Wx Gene. Plant Biotechnol. J. 19, 11-13.

  • Jin, S.1, Lin, Q.1, Gao, Q., and Gao, C.* (2023). Optimized prime editing in monocot plants using PlantPegDesigner and engineered plant prime editors (ePPEs). Nat. Protoc. 18, 831-853.

  • Liu, G.1, Lin, Q.1, Jin, S.1, and Gao, C.* (2022). The CRISPR-Cas toolbox and gene editing technologies. Mol. Cell 82, 333-347. (高被引论文)

  • Lin, Q.1, Zhou, Z.1, Luo, W., Fang, M., Li, M.*, and Li, H.* (2017). Screening of proximal and interacting proteins in rice protoplasts by proximity-dependent biotinylation. Front. Plant Sci. 8, 749.

  • Jiang, Y.Y.1, Chai, Y.P.1, Lu, M.H.1, Han, X.L., Lin, Q., Zhang, Y., Zhang, Q., Zhou, Y., Wang, X.C., Gao, C.*, and Chen, Q.J.* (2020). Prime editing efficiently generates W542L and S621I double mutations in two ALS genes in maize. Genome Biol. 21, 257.

  • Xue, C.1, Zhang, H.1, Lin, Q., Fan, R., and Gao, C.* (2018). Manipulating mRNA splicing by base editing in plants. Sci. China Life Sci. 61, 1293-1300. (封面故事)

  • Li, M.1, Li, X.1, Zhou, Z., Wu, P., Fang, M., Pan, X., Lin, Q., Luo, W., Wu, G.*, Li, H.* (2016). Reassessment of the Four Yield-related Genes Gn1a, DEP1, GS3, and IPA1 in Rice Using a CRISPR/Cas9 System. Front. Plant Sci. 7, 377. (高被引论文)

  • 罗婉冰, 林秋鹏, 李晓霞, 周泽娇, 阳辉勇, 杜荣裕, 李洪清.* (2017). 采用CELⅠ酶粗提物高效鉴定CRISPR/Cas9介导的基因突变. 生物工程学报 33, 775-784.