林秋鹏

华南农业大学农学院

课题组组长（PI）

作物基因编辑实验室 | 负责人

首聘教授 | 博士生导师

| 研究方向

主要围绕开发高效安全的精准编辑体系、并将该技术应用于农业育种及医疗领域等方面开展工作。以第一作者在国际上率先建立了适用于植物的引导编辑技术体系，并开发了多套提升该系统效率的全新方法，此外还开发了一系列基因组编辑新策略并应用于植物基因功能研究或分子育种，上述相关工作已申请多项PCT国际专利保护我国的知识产权。近年来以第一作者（含共同）身份在Cell、Nature Biotechnology（四篇）、Nature Protocols、Molecular Cell等国际权威杂志发表SCI论文10篇，累计影响因子超过350。

| 工作经历

2023-至今华南农业大学首聘教授
2021-2023, 中国科学院遗传与发育生物学研究所博士后

| 教育经历

2017-2021 博士, 中国科学院遗传与发育生物学研究所, 遗传学
2014-2017 硕士, 华南师范大学生命科学学院, 植物学
2010-2014 学士, 华南师范大学生命科学学院, 生命科学勷勤创新班
2007-2010 汕头市聿怀中学
2004-2007 汕头市飞厦中学

| 获奖情况

中国科学院优秀博士论文(“中科院百篇优博”)获得者
入选博士后创新人才支持计划(“博新计划”)

| 发表文章

林秋鹏¹*, 朱秀丽¹, 马琳莎, 姚鹏程. (2023). 引导编辑系统研究进展. 华南农业大学学报 (已接收).

Lin, Q.¹, Zong, Y.¹, Xue, C.¹, Wang, S., Jin, S., Zhu, Z., Wang, Y., Anzalone, A.V., Raguram, A., Doman, J.L., Liu, D.R., and Gao, C.* (2020). Prime genome editing in rice and wheat. Nat. Biotechnol. 38, 582-585. (Trends in Plant Science亮点评述; F1000Prime推荐)

Lin, Q.¹, Jin, S.¹, Zong, Y.¹, Yu, H.¹, Zhu, Z., Liu, G., Kou, L., Wang, Y., Qiu, J.L., Li, J.*, and Gao, C.* (2021). High-efficiency prime editing with optimized, paired pegRNAs in plants. Nat. Biotechnol. 39, 923-927. (高被引论文; Nature Methods亮点评述)

Huang, J.¹, Lin, Q.¹, Fei, H.¹, He, Z.¹, Xu, H., Li, Y., Qu, K., Han, P., Gao, Q., Li, B., Liu, G., Zhang, L., Hu, J., Zhang, R., Zuo, E., Luo, Y., Ran, Y., Qiu, J.L., Zhao, K.T.*, and Gao, C.* (2023). Discovery of deaminase functions by structure-based protein clustering. Cell. 186, 3182-3195.e14. (Trends in Plant Science亮点评述; F1000Prime推荐)

Jin, S.¹, Lin, Q.¹, Luo, Y.¹, Zhu, Z.¹, Liu, G., Li, Y., Chen, K., Qiu, J.L., and Gao, C.* (2021). Genome-wide specificity of prime editors in plants. Nat. Biotechnol. 39, 1292-1299. (高被引论文; Nature Methods亮点评述)

Wang, S.¹, Zong, Y.¹, Lin, Q.¹, Zhang, H.¹, Chai, Z., Zhang, D., Chen, K., Qiu,J.L., and Gao, C.* (2020). Precise, predictable multi-nucleotide deletions in rice and wheat using APOBEC-Cas9. Nat. Biotechnol. 38, 1460-1465.

Lin, Q.¹, Zhu, Z.¹, Liu, G.¹, Sun, C., Lin, D., Xue, C., Li, S., Zhang, D., Gao, C., Wang, Y.*, and Qiu, J.L.* (2021). Genome editing in plants with MAD7 nuclease. J. Genet. Genomics. 48, 444-451. (封面故事)

Xu, Y.¹, Lin, Q.¹, Li, X., Wang, F., Chen, Z., Wang, J., Li, W., Fan, F., Tao, Y., Jiang, Y., Wei, X., Zhang, R., Zhu, Q.H., Bu, Q.*, Yang, J.*, and Gao, C.* (2021). Fine-tuning the amylose content of rice by precise base editing of the Wx Gene. Plant Biotechnol. J. 19, 11-13.

Jin, S.¹, Lin, Q.¹, Gao, Q., and Gao, C.* (2023). Optimized prime editing in monocot plants using PlantPegDesigner and engineered plant prime editors (ePPEs). Nat. Protoc. 18, 831-853.

Liu, G.¹, Lin, Q.¹, Jin, S.¹, and Gao, C.* (2022). The CRISPR-Cas toolbox and gene editing technologies. Mol. Cell 82, 333-347. (高被引论文)

Lin, Q.¹, Zhou, Z.¹, Luo, W., Fang, M., Li, M.*, and Li, H.* (2017). Screening of proximal and interacting proteins in rice protoplasts by proximity-dependent biotinylation. Front. Plant Sci. 8, 749.

Jiang, Y.Y.¹, Chai, Y.P.¹, Lu, M.H.¹, Han, X.L., Lin, Q., Zhang, Y., Zhang, Q., Zhou, Y., Wang, X.C., Gao, C.*, and Chen, Q.J.* (2020). Prime editing efficiently generates W542L and S621I double mutations in two ALS genes in maize. Genome Biol. 21, 257.

Xue, C.¹, Zhang, H.¹, Lin, Q., Fan, R., and Gao, C.* (2018). Manipulating mRNA splicing by base editing in plants. Sci. China Life Sci. 61, 1293-1300. (封面故事)

Li, M.¹, Li, X.¹, Zhou, Z., Wu, P., Fang, M., Pan, X., Lin, Q., Luo, W., Wu, G.*, Li, H.* (2016). Reassessment of the Four Yield-related Genes Gn1a, DEP1, GS3, and IPA1 in Rice Using a CRISPR/Cas9 System. Front. Plant Sci. 7, 377. (高被引论文)

罗婉冰, 林秋鹏, 李晓霞, 周泽娇, 阳辉勇, 杜荣裕, 李洪清.* (2017). 采用CELⅠ酶粗提物高效鉴定CRISPR/Cas9介导的基因突变. 生物工程学报 33, 775-784.